A new TaqI polymorphism of the complement factor B gene.

A new TaqI polymorphism of the complement factor B gene SOURCE/DESCRIPTION : A full length factor B cDNA insert from clone pFB3B (1) which detects the TaqI polymorphism previously described at the C2 and BF loci (2). POLYMORPHISM : TaqI (TjCGA) identifies a new allele resulting from an additional site subdividing the 3.1 kb fragment of the BF gene (2) into two fragments of 1.9 and 1.2 kb. CHROMOSOMAL LOCALIZATION : On the short arm of chromosome 6, between the gene for complement C2 and the C4A gene of the MHC. MENDELIAN INHERITANCE : Co-dominant segregation demonstrated in one Lebanese family Tsee figure) and in one French family. OTHER COMMENTS : Run on 0.8% agarose gel and hybridized under high stringency conditions.